HIV-1 Nef Employs Cellular Autophagy Machinery to Downregulate CD4
نویسندگان
چکیده
منابع مشابه
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
The Nef protein of HIV-1 downregulates the cell surface co-receptor CD4 by hijacking the clathrin adaptor complex AP-2. The structural basis for the hijacking of AP-2 by Nef is revealed by a 2.9 Å crystal structure of Nef bound to the α and σ2 subunits of AP-2. Nef binds to AP-2 via its central loop (residues 149-179) and its core. The determinants for Nef binding include residues that directly...
متن کاملDifferential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.
UNLABELLED HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication through superinfection resistance and other mechanisms. Nef sequence motifs that modulate these functions have been identified via in vitro mutagenesis with laboratory HIV-1 strains. However, it remains...
متن کاملHIV-1 Nef blocks autophagy in human astrocytes.
Comment on: Saribas AS, et al. Dysregulation of autophagy by HIV-1 Nef in human astrocytes. Cell Cycle 2015;14(18):2899–904; PMID: 26176554; http://dx.doi.org/10.1080/15384101.2015.1069927. Luca Sardo, Sergey Iordanskiy, Zachary Klase, and Fatah Kashanchi*; Department of Biological Sciences; University of the Sciences; Philadelphia, PA USA; National Center for Biodefense and Infectious Diseases...
متن کاملInteractions of HIV-1 NEF with cellular signal transducing proteins.
Nef is a 27 - 34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques (1). In a transgenic mouse model expression of Nef protein alone when expressed under a CD4-promoter is sufficient to cause an AIDS like disease (2). A critical role for Nef in development of AIDS in humans i...
متن کاملHIV-1 Nef disrupts maturation of CD4+ T cells through CD4/Lck modulation.
The HIV-1 Nef protein is a major determinant of HIV-1 pathogenicity. It has been found to induce thymocyte depletion, but the mechanisms involved are not completely understood. Also, nothing is known about its effects on thymocyte selection. We used the CD4C/HIV(Nef) transgenic (Tg) mice, which develop a profound CD4(+) T cell lymphopenia, to study their thymic development. We report that HIV-1...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2060